Functional genomics, an integrated approach. Final report for the Trieste component | Zendy

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Functional genomics, an integrated approach. Final report for the Trieste component

Author(s) -

Andrew Bradbury

Publication year - 1999

Publication title -

osti oai (u.s. department of energy office of scientific and technical information)

Language(s) - English

Resource type - Reports

DOI - 10.2172/810688

Subject(s) - phage display , phagemid , encode , computational biology , gene , functional genomics , genomic library , biology , genetics , genomics , fragment (logic) , bacteriophage , genome , antibody , computer science , peptide sequence , programming language , escherichia coli

Phage display offers the possibility of selecting polypeptides (and the genes which encode them) from libraries of 10 billion or more different polypeptides on the basis of their abilities to bind target proteins and subdomains. The general principle of phage display relies on the coupling of phenotype and genotype in the phage. The specific aims of this project were threefold: (1) to produce a large phagemid antibody library; (2) to develop a general method for deriving antibodies against the protein products of cloned genes; (3) to develop technologies which permit the display of gene fragment libraries on phage. Accomplishments in each of these areas are presented

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