Bacterial nickel metabolism and storage. Final report for the period January 1, 1999 - March 31, 2002

Nickel is an element required for the growth of many microorganisms, as the metal functions as a key component of a metal center for several enzymes. For the organisms that rely on nickel, the metal must be transported, temporarily stored or sequestered, and then processed by accessory proteins for proper metal center assembly into the designated enzyme. The research conducted for this project addressed the nature and roles of key proteins that are involved in the above Ni-enzyme expression/synthesis process