Human Genetic Marker for Resistance to Radiation and Chemicals | Zendy

D. Lieberman | Zendy

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Human Genetic Marker for Resistance to Radiation and Chemicals

Author(s) -

D. Lieberman

Publication year - 2001

Publication title -

osti oai (u.s. department of energy office of scientific and technical information)

Language(s) - English

Resource type - Reports

DOI - 10.2172/789807

Subject(s) - gene , hazardous waste , biology , yeast , genetics , biomarker , dna damage , computational biology , human cell , human health , dna , ecology , medicine , environmental health

TO characterize the human HRDAD9 gene and evaluate its potential as a biomarker to predict susceptibility to the deleterious health effects potentially caused by exposure to radiations or chemicals present at DOE hazardous waste cleanup sites. HRAD9 is a human gene that is highly conserved throughout evolution. Related genes have been isolated from yeasts and mice, underscoring its biological significance. Most of our previous work involved characterization of the yeast gene cognate, wherein it was determined that the corresponding protein plays a significant role in promoting resistance of cells to radiations and chemicals, and in particular, controlling cell growth in response to DNA damage

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