Open AccessStructure, dynamics, and function of biomolecules
Author(s) -
Hans Frauenfelder,
Joel Berendzen,
A. E. Garcia,
Goutam Gupta,
G. A. Olah,
Thomas C. Terwilliger,
Jill Trewhella,
Cameron C. Wood,
William H. Woodruff
Publication year - 1998
Language(s) - English
Resource type - Reports
DOI - 10.2172/674922
Subject(s) - national laboratory , function (biology) , biomolecular structure , neutron scattering , multidisciplinary approach , systems engineering , resource (disambiguation) , computer science , nanotechnology , physics , neutron , engineering , engineering physics , nuclear physics , biology , materials science , political science , protein structure , computer network , nuclear magnetic resonance , evolutionary biology , law
This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The authors enhanced Los Alamos' core competency in Bioscience and Biotechnology by building on present strengths in experimental techniques, theory, high-performance computing, modeling, and simulation applied to biomolecular structure, dynamics, and function. Specifically, the authors strengthened their capabilities in neutron/x-ray scattering, x-ray crystallography, NMR, laser, and optical spectroscopies. Initially they focused on supporting the Los alamos Neutron Science Center (LANSCE) in the design and implementation of new neutron scattering instrumentation, they developed new methods for analysis of scattering data, and they developed new projects to study the structures of biomolecular complexes. The authors have also worked to strengthen interactions between theory and experiment, and between the biological and physical sciences. They sponsored regular meetings of members from all interested LANL technical divisions, and supported two lecture series: ''Biology for Physicists'' and ''Issues in Modern Biology''. They also supported the formation of interdisciplinary/inter-divisional teams to develop projects in science-based bioremediation and an integrated structural biology resource. Finally, they successfully worked with a multidisciplinary team to put forward the Laboratory's Genome and Beyond tactical goal