Open AccessChanges in gene expression following EMF exposure
Author(s) -
G E Woloschak,
T Paunesku,
C M Chang-Liu,
L Loberg,
J Gauger,
D McCormick
Publication year - 1997
Language(s) - English
Resource type - Reports
DOI - 10.2172/563249
Subject(s) - gene expression , gene , ionizing radiation , biology , regulation of gene expression , microbiology and biotechnology , biological effect , biological pathway , genetics , endocrinology , irradiation , physics , nuclear physics
Experiments were designed to examine the effects of electromagnetic field (EMF) exposure on specific gene expression, an effect that can be deleterious, beneficial, or neutral, depending on the long-term consequences; however, the proof of a reproducible, quantitative biological effect (such as change in gene expression) will lead to latter experiments aimed at determining the relative contribution of these changes to cellular consequences. Past work by ourselves and by others has shown that measures of gene expression are extremely sensitive indicators of the cellular and biological effects of ionizing radiation, with transcriptional changes being detected by exposure of cells to doses of {gamma}-rays as low as 0.01 cGy that have no pronounced cellular consequences. On the basis of this work, the authors hypothesized that measures of gene expression will be equally sensitive to EMF effects on cells