Emerging pathogens: Dynamics, mutation and drug resistance | Zendy

A.S. Perelson | Zendy; Beth P. Goldstein | Zendy; Bette Korber | Zendy

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Emerging pathogens: Dynamics, mutation and drug resistance

Author(s) -

A.S. Perelson,

Beth P. Goldstein,

Bette Korber

Publication year - 1997

Publication title -

osti oai (u.s. department of energy office of scientific and technical information)

Language(s) - English

Resource type - Reports

DOI - 10.2172/534529

Subject(s) - rimantadine , drug resistance , drug , virology , antiviral drug , drug development , biology , medicine , computational biology , influenza a virus , pharmacology , virus , microbiology and biotechnology

This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The objectives of this project were to develop models of the spread of pathogens, such as HIV-1 and influenza, in humans, and then to use the models to address the possibility of designing appropriate drug therapies that may limit the ability of the pathogen to escape treatment by mutating into a drug resistant form. We have developed a model of drug-resistance to amantidine and rimantadine, the two major antiviral drugs used to treat influenza, and have used the model to suggest treatment strategies during an epidemic

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