Open AccessMultagenicity of radon and radon daughters. Final technical report, January 1, 1993--December 31, 1996
Author(s) -
Helen H. Evans
Publication year - 1997
Language(s) - English
Resource type - Reports
DOI - 10.2172/491414
Subject(s) - radon , radon daughters , dna , radiochemistry , radiation dose , radiation , lymphoblast , toxicology , radiation exposure , chemistry , nuclear medicine , biology , genetics , medicine , physics , nuclear physics , cell culture
The objective of this research was to investigate the dose-response relationship with regard to the lethal and mutagenic effects of exposure of cells to radon and its decay products. Dose-rate dependence was studied, as well as the nature of the DNA lesions. The effect of DNA repair on the lethal and mutagenic effects of exposure and on the character of the DNA lesions was investigated by comparing the response of L5178Y strains that differ in their ability to rejoin X radiation-induced DNA double strand breaks. The nature of radon/radon daughter-induced mutational lesions in human lymphoblasts was also investigated