Receptor-DNA binding to target auger electrons for cancer therapy. Final report, August 1, 1993--January 31, 1997 | Zendy

Eugene R. DeSombre | Zendy

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Receptor-DNA binding to target auger electrons for cancer therapy. Final report, August 1, 1993--January 31, 1997

Author(s) -

Eugene R. DeSombre

Publication year - 1997

Publication title -

osti oai (u.s. department of energy office of scientific and technical information)

Language(s) - English

Resource type - Reports

DOI - 10.2172/477720

Subject(s) - dna , auger effect , auger , in vivo , radiation therapy , cancer , cancer research , estrogen receptor , cancer therapy , in vitro , receptor , biophysics , auger electron spectroscopy , chemistry , microbiology and biotechnology , medicine , biology , breast cancer , physics , biochemistry , genetics , atomic physics , nuclear physics

The goal of this program was to investigate the principle of receptor-DNA binding as a means to target Auger electron radiation for cancer therapy, and thereby to evaluate the potential of non-covalent, high-affinity, Auger electron-emitting ligands binding to a DNA associated molecule, or DNA itself, for cancer therapy. These studies were intended to assess the ability of Auger-emitting estrogens to kill estrogen receptor-positive tumor cells, determine the mean lethal dose, and determine whether they could be effective in vitro and in vivo

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