Enzyme catalysts for a biotechnology-based chemical industry. Quarterly progress report, April 1--June 28, 1996 | Zendy

Frances H. Arnold | Zendy

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Enzyme catalysts for a biotechnology-based chemical industry. Quarterly progress report, April 1--June 28, 1996

Author(s) -

Frances H. Arnold

Publication year - 1996

Publication title -

osti oai (u.s. department of energy office of scientific and technical information)

Language(s) - English

Resource type - Reports

DOI - 10.2172/383575

Subject(s) - esterase , biochemical engineering , industrial biotechnology , subtilisin , mutagenesis , chemical industry , enzyme , catalysis , microbiology and biotechnology , chemistry , engineering , mutant , biochemistry , biology , organic chemistry , gene

The goal of this research is to engineer enzymes to be efficient and economically attractive catalysts for the chemical industry. The author is attempted to demonstrate generally-applicable approaches to enzyme improvement as well as develop specific catalysts for potential industrial application. The paper describes the progress in two projects: (a) Random mutagenesis of pNB esterase: Improved activity and stability; and (2) Subtilisin mutants exhibiting improved ligase activity in organic solvents

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