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Dynamic spatial organization of multi-protein complexes controlling microbial polar organization, chromosome replication, and cytokinesis
Author(s) -
Harley H. McAdams,
Lucille Shapiro,
Mark C. Horowitz,
Gary L. Andersen,
Kenneth H. Downing,
Thomas Earnest,
Mark H. Ellisman,
Zemer Gitai,
Carolyn A. Larabell,
Patrick H. Viollier
Publication year - 2012
Publication title -
osti oai (u.s. department of energy office of scientific and technical information)
Language(s) - English
Resource type - Reports
DOI - 10.2172/1043294
Subject(s) - cytokinesis , replication (statistics) , polar , dna replication , computational biology , microbiology and biotechnology , biology , computer science , nanotechnology , cell , genetics , materials science , dna , physics , cell division , virology , astronomy
This project was a program to develop high-throughput methods to identify and characterize spatially localized multiprotein complexes in bacterial cells. We applied a multidisciplinary “systems engineering” approach to the detailed characterization of localized multi-protein structures in vivo – a problem that has previously been approached on a fragmented, piecemeal basis

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