Quantitative analysis of glutathione and cysteine S-conjugates of microcystin-LR in the liver, kidney and muscle of common carp (Cyprinus carpio) in Lake Taihu | Zendy

Laiyan Wu | Zendy; Songbo Wang | Zendy; Min Tao | Zendy; Ping Xie | Zendy; Jun Chen | Zendy

Open Access

Quantitative analysis of glutathione and cysteine S-conjugates of microcystin-LR in the liver, kidney and muscle of common carp (Cyprinus carpio) in Lake Taihu

Author(s) -

Laiyan Wu,

Songbo Wang,

Min Tao,

Ping Xie,

Jun Chen

Publication year - 2016

Publication title -

journal of water and health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.482

H-Index - 59

eISSN - 1996-7829

pISSN - 1477-8920

DOI - 10.2166/wh.2016.139

Subject(s) - cyprinus , common carp , carp , glutathione , cysteine , kidney , chemistry , microcystin lr , environmental chemistry , environmental science , fishery , biology , biochemistry , endocrinology , fish <actinopterygii> , cyanobacteria , genetics , bacteria , enzyme

Tissue distribution of microcystin (MC)-LR-GSH, MC-LR-Cys and MC-LR of omnivorous fish in Lake Taihu was investigated. MC-LR and MC-LR-Cys were detected in liver, kidney and muscle. The concentration of MC-LR in liver and kidney was 0.052 μg g -1 DW and 0.067 μg g -1 DW, respectively. MC-LR-Cys appeared to be an important metabolite with average contents of 1.104 μg g -1 DW and 0.724 μg g -1 DW in liver and kidney, and the MC-LR-Cys/MC-LR ratio in liver and kidney reaching as high as 21.4 and 10.8. High MC-LR-Cys/MC-LR ratio and a significant correlation between MC-LR-Cys and MC-LR concentration in liver, suggest that liver is more active in detoxification of MC-LR by formation of MC-LR-Cys for omnivorous fish. Furthermore, there might be a balance between the accumulation and depuration/metabolism of MC-LR-Cys in kidney. The MC-LR-Cys can be formed in kidney directly, or transported from liver or other tissues, while the MC-LR-Cys in kidney might be dissociated to MC-LR or excreted. Although MC-LR and its metabolites were scarcely detected in muscle, it is necessary to investigate the distribution of toxic metabolites in edible muscle.

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