Development of a quaternized chitosan with enhanced antibacterial efficacy | Zendy

Gurpreet Kaur Khaira | Zendy; Rashmi Kumariya | Zendy; Manmohan Chibber | Zendy; Moushumi Ghosh | Zendy

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Development of a quaternized chitosan with enhanced antibacterial efficacy

Author(s) -

Gurpreet Kaur Khaira,

Rashmi Kumariya,

Manmohan Chibber,

Moushumi Ghosh

Publication year - 2013

Publication title -

journal of water and health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.482

H-Index - 59

eISSN - 1996-7829

pISSN - 1477-8920

DOI - 10.2166/wh.2013.029

Subject(s) - chitosan , listeria monocytogenes , chemistry , antibacterial activity , aeromonas hydrophila , escherichia coli , yersinia enterocolitica , ammonium , microbiology and biotechnology , lactate dehydrogenase , bacteria , nuclear chemistry , food science , biochemistry , biology , enzyme , organic chemistry , genetics , gene

The antibacterial activity of a water-soluble chitosan derivative prepared by chemical modification to quaternary ammonium compound N,N,N-trimethylchitosan (TC) was investigated against four selected waterborne pathogens: Aeromonas hydrophila ATCC 35654, Yersinia enterocolitica ATCC 9610, Listeria monocytogenes ATCC 19111 and Escherichia coli O157:H7 ATCC 32150. An inactivation of 4 log CFU/ml of all waterborne pathogens was noted for the quaternized chitosan as compared with chitosan over a short contact time (30 min) and low dosage (4.5 ppm) at ambient temperature. A marked increase in glucose level, protein content and lactate dehydrogenase (LDH) activity was observed concurrently in the cell supernatant to be a major bactericidal mechanism. The results suggest that the TC derivative may be a promising commercial substitute for acid-soluble chitosan for rapid and effective disinfection of water.

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