Virulence factor activity relationships for hepatitis E and Cryptosporidium | Zendy

Ronald Fayer | Zendy; Palmer A. Orlandi | Zendy; Michael L. Perdue | Zendy

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Virulence factor activity relationships for hepatitis E and Cryptosporidium

Author(s) -

Ronald Fayer,

Palmer A. Orlandi,

Michael L. Perdue

Publication year - 2009

Publication title -

journal of water and health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.482

H-Index - 59

eISSN - 1996-7829

pISSN - 1477-8920

DOI - 10.2166/wh.2009.044

Subject(s) - virulence , biology , genotype , cryptosporidium , organism , virology , microbiology and biotechnology , host (biology) , immune system , host factors , disease , gene , virus , immunology , genetics , feces , medicine , pathology

The hepatitis E virus and Cryptosporidium are waterborne pathogens, each consisting of distinct taxa, genotypes and isolates that infect humans, nonhuman animal species or both. Some are associated with disease, others are not. Factors contributing to disease are extremely complicated, possibly involving differences in one or more traits associated with an organism's taxon, genotype or isolate and its infectious dose, and age or condition, as well as the host's physiology and immune status. Potential virulence factors have not yet been identified for HEV. Putative virulence factors for Cryptosporidium might be found in recently recognized genes involved in processes such as excystation, adherence to host cells, invasion, intracellular maintenance and host cell destruction.

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