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Purpose: Composite measures have the potential to account for many of the facets of disease in chronic obstructive pulmonary disease (COPD). The purpose of this study was to investigate the relationship between the DOSE ( Dyspnea, Obstruction, Smoking, Exacerbation) index which is a multi-component assessment tool and handgrip and respiratory muscle strength, activities of daily living (ADL) and health-related quality of life in patients COPD. Methods : Forty-five patients with COPD (30 males, 15 females, mean FEV 1 =50.6±16.0%) were included. The DOSE index was calculated using the MRC dyspnea scale, obstruction level, smoking status, and exacerbation rate. Inspiratory and expiratory muscle strength (MIP-MEP) was measured with a mouth-pressure device. Handgrip strength was measured using hand dynamometer. Activities of daily living were evaluated using the London Chest ADL a-scale (LCADL) and quality of life was assessed using the disease-specific COPD Assessment Test (CAT). Results: The DOSE index score was related with handgrip strength (r=-0.397, p<0.05), MIP (r=-0.323, p=0.033), London Chest ADL-physical activity score (r=0.314, p=0.038), LCADL-leisure activities score (r=0.397, p=0.008), and CAT score (r=0.435, p=0.003). Conclusion: Increased multi-component disease severity is related with decreased handgrip and respiratory muscle strength, physical activity and leisure time activities of daily living, and worse health-related quality of life in COPD patients. The DOSE index, a simple disease severity assessment tool, is a convenient and practical tool for assessment in pulmonary rehabilitation programs.

KRONİK OBSTRÜKTİF AKCİĞER HASTALIĞINDA DOSE İNDEKSİ KAS FONKSİYON BOZUKLUĞU, GÜNLÜK YAŞAM AKTİVİTELERİ VE YAŞAM KALİTESİ İLE İLİŞKİLİDİR