Potential Effect of Alendronate on Tooth Eruption and Molar Root Formation in Young Growing and Osteoprotic Albino Rats (A Histological and Histochemical Study)

Aim: The aim of the present study to evaluate the potential effect of Sodium Alendronate on tooth eruption and root formation in young growing and osteoporotic albino rats .   Materials and Methods Sixty newborn wister albino rats with their average weight 6 grams, each were used in the study. Rats were divided into 4 groups (groupI, groupII, group III &group IV) : GI negative control, GII positive control, GIII Alendronat treated group, GIV (alendronate + dexamethasone) then each group was divided into 3 subgroups according to the date   of scarification at7,14,30 days. Rats were subjected to subcutaneous injection of sodium alendronate and dexamethasone in their dorsal back. The specimens were processed for histological and histochemical analysis. Results: alendronate prevented tooth eruption and root formation but dexamethasone caused resorption of bone over developing molar but didn’t affect molar eruption and root formation.   Conclusion: sodium alendronate caused increase in bone formation and obstructed eruption pathway. Sodium alendronate prevented maturation of alveolar bone while dexamethasone caused destruction of alveolar bone but didn’t affect normal tooth eruption.