The Effects of Different Extract of LepidiumSativum on Induced Periodontitis in Dexamethasone Immunosuppressed Rats

Objective : The present study was designated to evaluate the effect of lepidiumsativum extract on structure and density of bone in immunosuppressed rats with induced chronic periodontitis histologically, hostometrically as well as radiodensitometric analysis by digital radiography assessment (vista scan). Materials and methods: A total 36 wistar male rats were divided randomly into 6 groups (6 rats/group). The study sample was divided into:I Control group: in this group rats were fed with a normal diet.II-Control group with ligature: without receiving dexamethasone injection, a sub marginal cotton ligature.III-Vehicle group: in this group rats were received a weekly dose of dexamethasone for 6 weeks and received sub marginal cotton ligature (no treatment). SRP 1 (methanol group): rats were received methanol extract for 30 days, these were subjected to scaling and root planning (SRP). SRP 2 (watery group): in this group rats were subjected to (SRP). SRP 3 group submitted only to SRP and received no further treatment.Results: methanol extract has better anabolic effect on bone and regenerative on periodontal ligaments than watery extract.This could be explained by the fact that lepidiumsativum possesses anti-inflammatory, immunomodulatory properties and antioxidative activity that may resolve periodontal inflammation. Codex : 30/1707 dentaljournal.forgirls@yahoo.com