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[No abstract. Showing first paragraph of article] Pulmonary hypertension is a progressive disease characterized by an elevation of  pulmonary artery pressure and pulmonary vascular resistance, leading to right ventricular failure and death. It remains a challenging chronic progressive disease, but the current interest and advent of medical therapy in the last 20 years has significantly changed the perception of medical community in this disease. Pulmonary hypertension is not a specific disease; the majority of cases present with other diseases and various pathological processes that affect the pulmonary vasculature, and consequently increase pulmonary pressure and vascular resistance.

Pulmonary hypertension: From an orphan disease to a global epidemic