The effect of angiotensin receptor blockers on C-reactive protein and other circulating inflammatory indices in man | Zendy

Roberto Pedrinelli | Zendy

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The effect of angiotensin receptor blockers on C-reactive protein and other circulating inflammatory indices in man

Author(s) -

Roberto Pedrinelli

Publication year - 2009

Publication title -

vascular health and risk management

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.892

H-Index - 68

eISSN - 1178-2048

pISSN - 1176-6344

DOI - 10.2147/vhrm.s4800

Subject(s) - medicine , angiotensin ii , c reactive protein , inflammation , receptor , angiotensin receptor , tumor necrosis factor alpha , renin–angiotensin system , monocyte , endocrinology , immunology , blood pressure

Anti-inflammatory properties may contribute to the pharmacological effects of angiotensin II receptor blockers (ARBs), a leading therapeutic class in the management of hypertension and related cardiovascular and renal diseases. That possibility, supported by consistent evidence from in-vitro and animal studies showing pro-inflammatory properties of angiotensin II, has been evaluated clinically by measuring the effect of ARBs on C-reactive protein and other circulating indices of inflammation (e-selectin, adhesion molecules, interleukin-6, tissue necrosis factor-alpha, monocyte chemoattractant protein-1) of potential clinical relevance, a body of evidence that this paper aims to review.

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