Endoglin: a critical mediator of cardiovascular health | Zendy

Navin K. Kapur | Zendy; Kevin Morine | Zendy; Michelle Letarte | Zendy

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Endoglin: a critical mediator of cardiovascular health

Author(s) -

Navin K. Kapur,

Kevin Morine,

Michelle Letarte

Publication year - 2013

Publication title -

vascular health and risk management

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.892

H-Index - 68

eISSN - 1178-2048

pISSN - 1176-6344

DOI - 10.2147/vhrm.s29144

Subject(s) - endoglin , medicine , disease , mediator , cardiac fibrosis , superfamily , transforming growth factor , transforming growth factor beta , fibrosis , bioinformatics , receptor , genetics , biology , stem cell , cd34

Endoglin (CD105) is a type III auxiliary receptor for the transforming growth factor beta (TGFβ) superfamily. Several lines of evidence suggest that endoglin plays a critical role in maintaining cardiovascular homeostasis. Seemingly disparate disease conditions, including hereditary hemorrhagic telangiectasia, pre-eclampsia, and cardiac fibrosis, have now been associated with endoglin. Given the central role of the TGFβ superfamily in multiple disease conditions, this review provides a detailed update on endoglin as an evolving therapeutic target in the management of cardiovascular disease.

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