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Pharmacological and combined interventions for the acute depressive episode: focus on efficacy and tolerability
Author(s) -
Felipe Fregni,
Brui,
Renério Fráguas
Publication year - 2009
Publication title -
therapeutics and clinical risk management
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 55
eISSN - 1178-203X
pISSN - 1176-6336
DOI - 10.2147/tcrm.s5751
Subject(s) - tolerability , medicine , neurostimulation , antidepressant , discontinuation , sertraline , clinical trial , intensive care medicine , psychiatry , adverse effect , anxiety , stimulation
Use of antidepressants is the gold standard therapy for major depression. However, despite the large number of commercially available antidepressant drugs there are several differences among them in efficacy, tolerability, and cost-effectiveness. In addition the optimal augmentation strategy is still not clear when dealing with treatment-resistant depression, a condition that affects 15% to 40% of depressed patients.

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