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Prolonged-release melatonin (PRM) 2 mg is indicated for insomnia in patients aged 55 years and older. A recent double-blind placebo-controlled study demonstrated 6-month efficacy and safety of PRM in insomnia patients aged 18-80 and lack of withdrawal and rebound symptoms upon discontinuation.

Prolonged-release melatonin for insomnia &ndash; an open-label long-term study of efficacy, safety, and withdrawal

Prolonged-release melatonin for insomnia – an open-label long-term study of efficacy, safety, and withdrawal