Quantifying the impact of nonadherence patterns on exposure to oral immunosuppressants | Zendy

Maclean | Zendy; Marc Pfister | Zendy; Susan Zhou | Zendy; Amit Roy | Zendy; Vickie A Tuomari | Zendy; Michael Heifets | Zendy; Moskowitz | Zendy

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Quantifying the impact of nonadherence patterns on exposure to oral immunosuppressants

Author(s) -

Maclean,

Marc Pfister,

Susan Zhou,

Amit Roy,

Vickie A Tuomari,

Michael Heifets,

Moskowitz

Publication year - 2011

Publication title -

therapeutics and clinical risk management

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.719

H-Index - 55

eISSN - 1178-203X

pISSN - 1176-6336

DOI - 10.2147/tcrm.s16870

Subject(s) - medicine , cluster (spacecraft) , coefficient of variation , transplantation , drug , pharmacology , computer science , programming language , statistics , mathematics

Nonadherence to oral immunosuppressive drugs in renal transplant patients remains a major challenge. The objective of this study was to develop an adherence-exposure model that 1) quantifies the impact of nonadherence patterns on cyclosporine levels and 2) identifies nonadherence patterns that are associated with unfavorable transplantation outcomes.

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