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Vascular α2B-adrenoreceptors have the potential to increase blood pressure by mediating vasoconstriction. A nine-nucleotide deletion in the receptor enhances vasoconstriction and exacerbates hypertension. The aim of this study was to determine the association between insertion/deletion (I/D) polymorphism of the α2B-adrenoceptor and hypertension with and without diabetes.

application of clinical genetics

Association of deletion allele of insertion/deletion polymorphism in &amp;alpha;2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus