Association of deletion allele of insertion/deletion polymorphism in &alpha;2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus | Zendy

Amin Faisal Ellakwa | Zendy; Ibrahim | Zendy; Khader | Zendy; Safaa I. Tayel | Zendy; El-Helbawy | Zendy

Open Access

Association of deletion allele of insertion/deletion polymorphism in α2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus

Author(s) -

Amin Faisal Ellakwa,

Ibrahim,

Khader,

Safaa I. Tayel,

El-Helbawy

Publication year - 2012

Publication title -

the application of clinical genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.879

H-Index - 32

ISSN - 1178-704X

DOI - 10.2147/tacg.s33814

Subject(s) - medicine , genotype , diabetes mellitus , endocrinology , allele , blood pressure , polymorphism (computer science) , single nucleotide polymorphism , type 2 diabetes , essential hypertension , gene , biology , genetics

Vascular α2B-adrenoreceptors have the potential to increase blood pressure by mediating vasoconstriction. A nine-nucleotide deletion in the receptor enhances vasoconstriction and exacerbates hypertension. The aim of this study was to determine the association between insertion/deletion (I/D) polymorphism of the α2B-adrenoceptor and hypertension with and without diabetes.

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