Association analysis of genetic variations of eNOS and &alpha;2&szlig;1 integrin genes with type 2 diabetic retinopathy | Zendy

Amin Faisal Ellakwa | Zendy; Azmy Elshazly | Zendy; Abdelraouf Dawood | Zendy; Kelany Abdelhameed | Zendy; Abdelsatar Elghobashy | Zendy; Mai M. El-Daly | Zendy

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Association analysis of genetic variations of eNOS and α2ß1 integrin genes with type 2 diabetic retinopathy

Author(s) -

Amin Faisal Ellakwa,

Azmy Elshazly,

Abdelraouf Dawood,

Kelany Abdelhameed,

Abdelsatar Elghobashy,

Mai M. El-Daly

Publication year - 2012

Publication title -

the application of clinical genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.879

H-Index - 32

ISSN - 1178-704X

DOI - 10.2147/tacg.s31979

Subject(s) - enos , diabetic retinopathy , medicine , retinopathy , diabetes mellitus , pathogenesis , genotype , type 2 diabetes , endocrinology , allele , nitric oxide , nitric oxide synthase , biology , genetics , gene

Diabetic retinopathy (DR) is classically defined as a microvasculopathy that primarily affects the small blood vessels of the inner retina as a complication of diabetes mellitus. It has been suggested that nitric oxide (NO) and α2β1 integrin (a platelet receptor for collagen) play an important role in the pathogenesis of microvascular complications in DR.

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