Hematopoietic stem cell transplantation | Zendy

Mark Tuthill | Zendy; Eleftheria Hatzimichael | Zendy

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Hematopoietic stem cell transplantation

Author(s) -

Mark Tuthill,

Eleftheria Hatzimichael

Publication year - 2010

Publication title -

stem cells and cloning advances and applications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.606

H-Index - 22

ISSN - 1178-6957

DOI - 10.2147/sccaa.s6815

Subject(s) - stem cell , hematopoietic stem cell transplantation , transplantation , medicine , haematopoiesis , leukemia , human leukocyte antigen , immunology , acute leukemia , lymphoma , antigen , biology , genetics

More than 25,000 hematopoietic stem cell transplantations (HSCTs) are performed each year for the treatment of lymphoma, leukemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, and myelodysplastic and myeloproliferative syndromes. Before transplantation, patients receive intensive myeloablative chemoradiotherapy followed by stem cell "rescue." Autologous HSCT is performed using the patient's own hematopoietic stem cells, which are harvested before transplantation and reinfused after myeloablation. Allogeneic HSCT uses human leukocyte antigen (HLA)-matched stem cells derived from a donor. Survival after allogeneic transplantation depends on donor-recipient matching, the graft-versus-host response, and the development of a graft versus leukemia effect. This article reviews the biology of stem cells, clinical efficacy of HSCT, transplantation procedures, and potential complications.

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