Treatment of systemic sclerosis: potential role for stem cell transplantation | Zendy

Chris T. Derk | Zendy

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Treatment of systemic sclerosis: potential role for stem cell transplantation

Author(s) -

Chris T. Derk

Publication year - 2009

Publication title -

stem cells and cloning advances and applications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.606

H-Index - 22

ISSN - 1178-6957

DOI - 10.2147/sccaa.s5282

Subject(s) - mesenchymal stem cell , multiple sclerosis , medicine , transplantation , immune system , stem cell , hematopoietic stem cell transplantation , immunology , clinical trial , cell therapy , disease , pathology , biology , genetics

Hematopoietic stem cell transplantation may "reset" the immune reconstitution and induce self tolerance of autoreactive lymphocytes, and has been explored in the treatments for systemic sclerosis. Phase I/II trials have shown a satisfactory risk benefit ratio. The true benefit will be identified by two ongoing prospective, randomized phase III trials. Multipotent mesenchymal stromal cells (MSCs) possess antiproliferative, anti-inflammatory, and immunosuppressive properties. The use of MSCs has showed successful responses in patients with severe steroid-resistant acute graft versus host disease in phase II trials, and may be a potentially promising option for patients with systemic sclerosis.

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