Endogenous cardiac stem cells for the treatment of heart failure | Zendy

Mary KearnsJonker | Zendy; Mireya Fuentes | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Endogenous cardiac stem cells for the treatment of heart failure

Author(s) -

Mary KearnsJonker,

Mireya Fuentes

Publication year - 2013

Publication title -

stem cells and cloning advances and applications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.606

H-Index - 22

ISSN - 1178-6957

DOI - 10.2147/sccaa.s29221

Subject(s) - endogeny , stem cell , progenitor cell , myocardial infarction , regeneration (biology) , heart failure , medicine , cardiac function curve , animal studies , clinical trial , cardiology , biology , microbiology and biotechnology

Stem cell-based therapies hold promise for regenerating the myocardium after injury. Recent data obtained from phase I clinical trials using endogenous cardiovascular progenitors isolated directly from the heart suggest that cell-based treatment for heart patients using stem cells that reside in the heart provides significant functional benefit and an improvement in patient outcome. Methods to achieve improved engraftment and regeneration may extend this therapeutic benefit. Endogenous cardiovascular progenitors have been tested extensively in small animals to identify cells that improve cardiac function after myocardial infarction. However, the relative lack of large animal models impedes translation into clinical practice. This review will exclusively focus on the latest research pertaining to humans and large animals, including both endogenous and induced sources of cardiovascular progenitors.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research