Natural cocoa ingestion reduced liver damage in mice infected with Plasmodium berghei (NK65) | Zendy

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Natural cocoa ingestion reduced liver damage in mice infected with Plasmodium berghei (NK65)

Author(s) -

Frederick Kwaku Addai,

Aidoo,

Ahenkorah,

Hottor,

Gyan,

Bugyei

Publication year - 2012

Publication title -

research and reports in tropical medicine

Language(s) - English

Resource type - Journals

ISSN - 1179-7282

DOI - 10.2147/rrtm.s33149

Subject(s) - plasmodium berghei , alanine transaminase , aspartate transaminase , ingestion , biology , transaminase , immunology , medicine , endocrinology , malaria , biochemistry , enzyme , alkaline phosphatase

This study tested whether natural cocoa powder ingestion could mitigate hepatic injury coincident with murine malaria. Plasmodium berghei infection causes liver damage including hepatic sinusoidal distension, and elevated serum alanine transaminase (ALT) and aspartate transaminase (AST) levels. According to literature, these pathologies largely result from activity of reactive oxygen species (ROS) and may be extenuated by antioxidants.

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