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I read with great interest the article by Cosci et al in a recent issue of your journal.1 The article provides for highly interesting reading and is very thought-provoking. Interestingly, the past few years have seen the emergence of extensive data that establish a close association between the A118G single nucleotide polymorphism of the OPRM1 gene and opioid, alcohol, and nicotine dependence.

Close association between A118G single nucleotide polymorphism and opioid, alcohol, and nicotine dependence