Upregulation of nucleostemin in colorectal cancer and its effects on cell malignancy | Zendy

Xiaogang Zhong | Zendy; Bin Wei | Zendy; Zhenyu Zhang | Zendy

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Upregulation of nucleostemin in colorectal cancer and its effects on cell malignancy

Author(s) -

Xiaogang Zhong,

Bin Wei,

Zhenyu Zhang

Publication year - 2015

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s78461

Subject(s) - gene knockdown , cell cycle , gene silencing , cancer research , viability assay , flow cytometry , downregulation and upregulation , apoptosis , small interfering rna , cell cycle checkpoint , transfection , cell growth , colorectal cancer , g1 phase , metastasis , biology , medicine , cell culture , cancer , microbiology and biotechnology , gene , biochemistry , genetics

Nucleostemin (NS) is a new protein localized in the nucleolus of most stem cells and tumor cells, which regulates their self-renewal and cell cycle progression. The aim of this study was to investigate the expression of NS in colorectal cancer (CRC) and the effects of NS knockdown in the Sw620 cell line to provide basis for clinical target therapy.

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