Primary primitive neuroectodermal tumor of the cervix | Zendy

Ling Ouyang | Zendy; Bo Li | Zendy; Xue Han | Zendy; Yang Zhou | Zendy; Xin Tong | Zendy; Shulang Zhang | Zendy; Zhang | Zendy

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Primary primitive neuroectodermal tumor of the cervix

Author(s) -

Ling Ouyang,

Bo Li,

Xue Han,

Yang Zhou,

Xin Tong,

Shulang Zhang,

Zhang

Publication year - 2013

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s45889

Subject(s) - primitive neuroectodermal tumor , immunohistochemistry , enolase , pathology , cd99 , medicine , cd117 , vimentin , cervix , radiation therapy , neoplasm , biology , cd34 , stem cell , cancer , genetics

Primary primitive neuroectodermal tumors (PNETs) are rare and high-grade malignant tumors that mostly occur in children and young adults. The most common sites are the trunk, limbs, and retroperitoneum. Herein, we present a case of a PNET involving the cervix uteri in a 27-year-old woman. The lesion showed characteristic histologic features of a PNET and was positive for the immunohistochemical markers cluster of differentiation (CD) 99, vimentin, neuron-specific enolase, neural cell adhesion molecule 1 (CD56), and CD117 (c-kit), further defining the tumor while helping to confirm PNET. The clinical Stage IIIB tumor was treated with chemotherapy and radiotherapy.

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