Cyclin D1 affects epithelial&ndash;mesenchymal transition in epithelial ovarian cancer stem cell-like cells | Zendy

Weiguo Lü | Zendy; Jiao | Zendy; Huang | Zendy; Ye | Zendy; Huidong Shi | Zendy; Xiaodong Cheng | Zendy; Xinyu Wang | Zendy; Hu | Zendy; Xie | Zendy

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Cyclin D1 affects epithelial–mesenchymal transition in epithelial ovarian cancer stem cell-like cells

Author(s) -

Weiguo Lü,

Jiao,

Huang,

Ye,

Huidong Shi,

Xiaodong Cheng,

Xinyu Wang,

Hu,

Xie

Publication year - 2013

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s44177

Subject(s) - vimentin , cyclin d1 , cd24 , small interfering rna , transfection , microbiology and biotechnology , cd44 , epithelial–mesenchymal transition , cancer research , stem cell , biology , cell cycle , cancer stem cell , apoptosis , cell , cell culture , downregulation and upregulation , immunology , genetics , gene , immunohistochemistry

The association of cancer stem cells with epithelial-mesenchymal transition (EMT) is receiving attention. We found in our previous study that EMT existed from CD24- phenotype cells to their differentiated cells. It was shown that cyclin D1 functioned in sustaining self-renewal independent of CDK4/CDK6 activation, but its effect on the EMT mechanism in ovarian cancer stem cells is unclear.

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