Dendritic cells fused with different pancreatic carcinoma cells induce different T-cell responses | Zendy

Mitsunori Yamakawa | Zendy; Andoh | Zendy; Makino | Zendy

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Dendritic cells fused with different pancreatic carcinoma cells induce different T-cell responses

Author(s) -

Mitsunori Yamakawa,

Andoh,

Makino

Publication year - 2013

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s37916

Subject(s) - cytotoxicity , ctl* , peripheral blood mononuclear cell , cytotoxic t cell , dendritic cell , cell culture , cancer research , cytokine , immune system , immunology , biology , chemistry , microbiology and biotechnology , cd8 , in vitro , biochemistry , genetics

It is unclear whether there are any differences in the induction of cytotoxic T lymphocytes (CTL) and CD4(+)CD25(high) regulatory T-cells (Tregs) among dendritic cells (DCs) fused with different pancreatic carcinomas. The aim of this study was to compare the ability to induce cytotoxicity by human DCs fused with different human pancreatic carcinoma cell lines and to elucidate the causes of variable cytotoxicity among cell lines.

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