Upregulation of microRNA-100 predicts poor prognosis in patients with pediatric acute myeloid leukemia | Zendy

Wenxia Kuai | Zendy; Jin Bai | Zendy; Ze Hong | Zendy; Aiping Guo | Zendy

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Upregulation of microRNA-100 predicts poor prognosis in patients with pediatric acute myeloid leukemia

Author(s) -

Wenxia Kuai,

Jin Bai,

Ze Hong,

Aiping Guo

Publication year - 2012

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s36017

Subject(s) - myeloid leukemia , downregulation and upregulation , medicine , microrna , myeloid , leukemia , cancer research , oncology , bioinformatics , gene , biology , genetics

MicroRNA-100 (miR-100), a small noncoding RNA molecule, acts as a tumor suppressor or an oncogene in different cancers. The aberrant expression of this microRNA has been demonstrated as a frequent event in adult patients with acute myeloid leukemia (AML), but little is known for pediatric AML. The aim of this study was to investigate the expression and clinical significance of miR-100 in pediatric AML.

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