Open Access<p>MicroRNA-126 Inhibit Viability of Colorectal Cancer Cell by Repressing mTOR Induced Apoptosis and Autophagy</p>
Author(s) -
Wei Li,
Zhanhong Chen,
Na Cheng,
Xing Li,
Jie Chen,
DongHao Wu,
Min Dong,
Xiangyuan Wu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s238348
Subject(s) - autophagy , viability assay , pi3k/akt/mtor pathway , apoptosis , microrna , cancer research , cell growth , carcinogenesis , biology , flow cytometry , microbiology and biotechnology , cancer , gene , biochemistry , genetics
Our study demonstrated that miR-126-induced can regulate the activity of CRC cells via autophagy and apoptosis and suggested a new mechanism of miR-126-mTOR interaction in CRC pathogenesis.
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