Long Non-Coding RNA LEF1-AS1 Promotes Migration, Invasion and Metastasis of Colon Cancer Cells Through miR-30-5p/SOX9 Axis | Zendy

Ting Sun | Zendy; Zhexian Liu | Zendy; Rui Zhang | Zendy; Siping Ma | Zendy; Tao Lin | Zendy; Yanxi Li | Zendy; Shihua Yang | Zendy; Wanchuan Zhang | Zendy; Yongpeng Wang | Zendy

Open Access

<p>Long Non-Coding RNA LEF1-AS1 Promotes Migration, Invasion and Metastasis of Colon Cancer Cells Through miR-30-5p/SOX9 Axis</p>

Author(s) -

Ting Sun,

Zhexian Liu,

Rui Zhang,

Siping Ma,

Tao Lin,

Yanxi Li,

Shihua Yang,

Wanchuan Zhang,

Yongpeng Wang

Publication year - 2020

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s232839

Subject(s) - gene knockdown , long non coding rna , metastasis , cancer research , carcinogenesis , downregulation and upregulation , colorectal cancer , biology , cell migration , gentamicin protection assay , cell growth , viability assay , cell , cancer , cell culture , gene , biochemistry , genetics

Aberrant expression of long non-coding RNAs (lncRNAs) has been implicated in the tumorigenesis and progression of colon cancer. Lymphoid enhancer-binding factor 1 antisense RNA 1 (LEF1-AS1), a highly conserved and newly discovered long non-coding RNA, has been reported to be upregulated and correlated with poor prognosis in colon cancer, but the exact role of it remains uncertain.

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