Icariin Mitigates the Growth and Invasion Ability of Human Oral Squamous Cell Carcinoma via Inhibiting Toll-Like Receptor 4 and Phosphorylation of NF-κB P65 | Zendy

Ke Lei | Zendy; Bing Ma | Zendy; Ping Shi | Zendy; Jin Che | Zendy; Ling Tan | Zendy; Longjiang Li | Zendy; Xiangyi He | Zendy; Lunchang Wang | Zendy

Open Access

<p>Icariin Mitigates the Growth and Invasion Ability of Human Oral Squamous Cell Carcinoma via Inhibiting Toll-Like Receptor 4 and Phosphorylation of NF-κB P65</p>

Author(s) -

Ke Lei,

Bing Ma,

Ping Shi,

Jin Che,

Ling Tan,

Longjiang Li,

Xiangyi He,

Lunchang Wang

Publication year - 2020

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s214514

Subject(s) - icariin , in vivo , cancer research , viability assay , tlr4 , western blot , cell growth , phosphorylation , receptor , chemistry , in vitro , pharmacology , medicine , biology , pathology , microbiology and biotechnology , biochemistry , alternative medicine , gene

Oral squamous cell carcinoma (OSCC) is an aggressive malignancy worldwide. Icariin (ICA), an active ingredient of flavonoids, has been demonstrated to possess antitumor activity in diverse cancers. Whereas, the role of ICAin OSCC is still unclear.

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