MicroRNA-155-3p promotes breast cancer progression through down-regulating CADM1 | Zendy

Guochao Zhang | Zendy; Lele Zhong | Zendy; Hao Luo | Zendy; Shibing Wang | Zendy

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<p>MicroRNA-155-3p promotes breast cancer progression through down-regulating CADM1</p>

Author(s) -

Guochao Zhang,

Lele Zhong,

Hao Luo,

Shibing Wang

Publication year - 2019

Publication title -

oncotargets and therapy

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s206180

Subject(s) - carcinogenesis , breast cancer , cancer research , microrna , mir 155 , cancer , cell growth , biology , transfection , apoptosis , flow cytometry , medicine , cell culture , microbiology and biotechnology , gene , biochemistry , genetics

Cell adhesion molecule 1 (CADM1) functions as a tumor suppressor and has been identified to be frequently inactivated in breast cancer, and closely associated with patients' poor prognosis and advanced TNM stage. However, the mechanisms underlying CADM1 in breast cancer progression remains incompletely clear. miR-155, a predicted modulator of CADM1 was reported to be overexpressed in breast cancer, and its high expression level was closely related to the malignant progression of breast cancer. The present study aimed to explore whether miR-155-3p could modulate CADM1 expression and then involved in the progression of breast cancer.

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