Impact of CXCR4 and CXCR7 knockout by CRISPR/Cas9 on the function of triple-negative breast cancer cells | Zendy

Yang Meng | Zendy; Chen Zeng | Zendy; Peiting Li | Zendy; Liyuan Qian | Zendy; Boni Ding | Zendy; Lihua Huang | Zendy; Gang Li | Zendy; Han Jiang | Zendy; Ni Gong | Zendy; Wei Wu | Zendy

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<p>Impact of CXCR4 and CXCR7 knockout by CRISPR/Cas9 on the function of triple-negative breast cancer cells</p>

Author(s) -

Yang Meng,

Chen Zeng,

Peiting Li,

Liyuan Qian,

Boni Ding,

Lihua Huang,

Gang Li,

Han Jiang,

Ni Gong,

Wei Wu

Publication year - 2019

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s195661

Subject(s) - knockout mouse , triple negative breast cancer , cancer research , gene knockout , breast cancer , cancer , metastasis , cxcr4 , cell growth , cell cycle , cell migration , flow cytometry , biology , cell , medicine , immunology , receptor , chemokine , gene , genetics

The knockout of the CXCR4 and CXCR7 genes affects the binding capacity and functions of CXCL12, inhibits the malignant progression of TNBC cells significantly, and may become a potential target for the treatment of TNBC.

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