Mst1-Hippo pathway triggers breast cancer apoptosis via inducing mitochondrial fragmentation in a manner dependent on JNK&ndash;Drp1 axis | Zendy

Hui Ouyang | Zendy; Enxiang Zhou | Zendy; Huan Wang | Zendy

Open Access

<p>Mst1-Hippo pathway triggers breast cancer apoptosis via inducing mitochondrial fragmentation in a manner dependent on JNK–Drp1 axis</p>

Author(s) -

Hui Ouyang,

Enxiang Zhou,

Huan Wang

Publication year - 2019

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s193787

Subject(s) - fragmentation (computing) , apoptosis , hippo signaling pathway , cancer research , microbiology and biotechnology , programmed cell death , mitochondrion , dna fragmentation , cancer cell , biology , chemistry , kinase , cancer , biochemistry , ecology , genetics

Mst1-Hippo pathway and mitochondrial fragmentation participate in the progression of several types of cancers. However, their roles in breast cancer requires investigation. The aim of our study is to determine whether Mst1 overexpression regulates the viability of breast cancer cells via modulating mitochondrial fragmentation.

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