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<p>TRIM31 promotes glioma proliferation and invasion through activating NF-&kappa;B pathway</p>
Author(s) -
Li Zhou,
Zhezhi Deng,
Haiyan Li,
Nan Jiang,
Zhisheng Wei,
Ming-Fan Hong,
Xiao-Dang Chen,
Jihui Wang,
Mingxing Zhang,
YiHua Shi,
Zhengqi Lu,
Xuming Huang
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s183625
Subject(s) - glioma , gene knockdown , cancer research , cell growth , nf κb , downregulation and upregulation , ubiquitin , chemistry , biology , cell culture , signal transduction , microbiology and biotechnology , biochemistry , gene , genetics
Glioma is the most lethal primary brain tumor, the survival rate still isn't improved in the past decades. It's essential to study the regulatory mechanism of glioma progression, hoping to find new therapy targets or methods. The family of tripartite motif (TRIM) containing proteins are E3 ubiquitination ligases, which play critical role in various tumor progression.

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