Open AccessEZH2 contributes to 5-FU resistance in gastric cancer by epigenetically suppressing FBXO32 expression
Author(s) -
ChenYu Wang,
Xingwang Li,
Junjie Zhang,
Zheng Ge,
Hejin Chen,
Junhong Hu
Publication year - 2018
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s180131
Subject(s) - gene knockdown , ezh2 , gene silencing , cancer research , cancer , downregulation and upregulation , chemistry , cell culture , biology , methylation , genetics , biochemistry , gene
Increasing evidence suggests the involvement of enhancer of zeste homologue 2 (EZH2) in chemoresistance of cancer treatment. Nevertheless, its function and molecular mechanisms in gastric cancer (GC) chemoresistance are still not well elucidated.
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