Open AccessHsp90 inhibitor NMS-E973 exerts the anticancer effect against glioblastoma via induction of PUMA-mediated apoptosis
Author(s) -
Libo Sun,
S.Y. Cindy Yang,
Guonan Chi,
Xingyi Jin
Publication year - 2018
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s160813
Subject(s) - puma , apoptosis , propidium iodide , annexin , cancer research , flow cytometry , mtt assay , viability assay , programmed cell death , medicine , biology , immunology , biochemistry
Glioblastoma is one of the most aggressive and common malignancies of the central nervous system in humans. Owing to the correlation of high Hsp90 expression with prognosis and clinical pathology features of diverse types of cancer, targeting Hsp90 with small-molecule inhibitors has become a promising anticancer strategy.
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