Antitumor effect of triptolide in T-cell lymphoblastic lymphoma by inhibiting cell viability, invasion, and epithelial&ndash;mesenchymal transition via regulating the PI3K/AKT/mTOR pathway | Zendy

Yan Huang | Zendy; Zhengwu Sun | Zendy; Yuan Zhang | Zendy; Lihua Wang | Zendy; Yan Guo | Zendy

Open Access

Antitumor effect of triptolide in T-cell lymphoblastic lymphoma by inhibiting cell viability, invasion, and epithelial–mesenchymal transition via regulating the PI3K/AKT/mTOR pathway

Author(s) -

Yan Huang,

Zhengwu Sun,

Yuan Zhang,

Lihua Wang,

Yan Guo

Publication year - 2018

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s149788

Subject(s) - jurkat cells , pi3k/akt/mtor pathway , protein kinase b , apoptosis , cancer research , triptolide , cell growth , chemistry , flow cytometry , t cell , biology , microbiology and biotechnology , immunology , biochemistry , immune system

T-cell lymphoblastic lymphoma (T-LBL) is a widely disseminated disease worldwide. Triptolide (TPL) is purified from Chinese herb and displays anti-inflammatory, anti-fertility, anti-tumor and immunosuppressive effects.

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