LEF1-AS1, a long non-coding RNA, promotes malignancy in glioblastoma | Zendy

Jin Wang | Zendy; Xiaoyang Liu | Zendy; Changsheng Yan | Zendy; Jie Liu | Zendy; Songtao Wang | Zendy; Yongzhi Hong | Zendy; Aihua Gu | Zendy; Peng Zhao | Zendy

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<em>LEF1-AS1</em>, a long non-coding RNA, promotes malignancy in glioblastoma

Author(s) -

Jin Wang,

Xiaoyang Liu,

Changsheng Yan,

Jie Liu,

Songtao Wang,

Yongzhi Hong,

Aihua Gu,

Peng Zhao

Publication year - 2017

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s130365

Subject(s) - gene knockdown , cancer research , long non coding rna , small interfering rna , cell growth , flow cytometry , glioma , biology , antisense rna , apoptosis , cell culture , microbiology and biotechnology , in vivo , cell , downregulation and upregulation , rna , transfection , gene , genetics

The long-noncoding RNAs (lncRNAs) are identified as new crucial regulators of diverse cellular processes in glioblastoma (GBM) tissues. However, the expression pattern and biological function of lncRNAs remain largely unknown. Here, for the first time, the effects of lncRNA lymphoid enhancer-binding factor 1 antisense RNA 1 ( LEF1-AS1 ) on GBM progression both in vitro and in vivo are investigated.

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