miR-139-5p regulates proliferation, apoptosis, and cell cycle of uterine leiomyoma cells by targeting TPD52 | Zendy

Hong Chen | Zendy; Hong Xu | Zendy; Yugang Meng | Zendy; Yun Zhang | Zendy; Junying Chen | Zendy; Xiaoning Wei | Zendy

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miR-139-5p regulates proliferation, apoptosis, and cell cycle of uterine leiomyoma cells by targeting TPD52

Author(s) -

Hong Chen,

Hong Xu,

Yugang Meng,

Yun Zhang,

Junying Chen,

Xiaoning Wei

Publication year - 2016

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s108890

Subject(s) - uterine leiomyoma , myometrium , leiomyoma , apoptosis , cell growth , cell cycle , western blot , transfection , cancer research , biology , medicine , pathology , gene , endocrinology , uterus , genetics

Uterine leiomyoma is one of the most common benign tumors in women. It dramatically decreases the quality of life in the affected women. However, there is a lack of effective treatment paradigms. Micro-RNAs are small noncoding RNA molecules that are extensively expressed in organisms, and they are interrelated with the occurrence and development of the tumor. miR-139-5p was found to be downregulated in various cancers, but its function and mechanism in uterine leiomyoma remain unknown. The aim of this study was to investigate the role of miR-139-5p and its target gene in uterine leiomyoma.

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