The important tumor suppressor role of PER1 in regulating the cyclin&ndash;CDK&ndash;CKI network in SCC15 human oral squamous cell carcinoma cells | Zendy

Kai Yang | Zendy; XiaoJuan Fu | Zendy; Han-Xue Li | Zendy; Dan Chen | Zendy; Hong Tang | Zendy

Open Access

The important tumor suppressor role of PER1 in regulating the cyclin–CDK–CKI network in SCC15 human oral squamous cell carcinoma cells

Author(s) -

Kai Yang,

XiaoJuan Fu,

Han-Xue Li,

Dan Chen,

Hong Tang

Publication year - 2016

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s100952

Subject(s) - cell cycle , cell growth , cancer research , apoptosis , biology , per1 , downregulation and upregulation , cyclin b1 , microbiology and biotechnology , cyclin dependent kinase 1 , chemistry , gene expression , clock , biochemistry , gene

Accumulating evidence suggests that the abnormal expression of the circadian clock gene PER1 is closely related to the development and progression of cancer. However, the exact molecular mechanism by which the abnormal expression of PER1 induces carcinogenesis is unclear. This study was conducted to investigate the alterations in downstream cell cycle genes, cell cycle distribution, cell proliferation, apoptosis, and in vivo tumorigenicity in SCC15 oral squamous cell carcinoma cells after PER1 downregulation.

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