Primary open angle glaucoma due to T377M MYOC: Population mapping of a Greek founder mutation in Northwestern Greece | Zendy

George Kitsos | Zendy; Zacharias Petrou | Zendy; Maria Grigoriadou | Zendy; John R. Samples | Zendy; Alex W. Hewitt | Zendy; Haris Kokotas | Zendy; Aglaia GiannouliaKarantana | Zendy; David A. Mackey | Zendy; Mary K. Wirtz | Zendy; Marilita Moschou | Zendy; John P.A. Ioannidis | Zendy; Michael B. Petersen | Zendy

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Primary open angle glaucoma due to T377M MYOC: Population mapping of a Greek founder mutation in Northwestern Greece

Author(s) -

George Kitsos,

Zacharias Petrou,

Maria Grigoriadou,

John R. Samples,

Alex W. Hewitt,

Haris Kokotas,

Aglaia GiannouliaKarantana,

David A. Mackey,

Mary K. Wirtz,

Marilita Moschou,

John P.A. Ioannidis,

Michael B. Petersen

Publication year - 2010

Publication title -

clinical ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.025

H-Index - 56

eISSN - 1177-5483

pISSN - 1177-5467

DOI - 10.2147/opth.s8974

Subject(s) - mutation , myocilin , genotyping , medicine , founder effect , genetics , population , open angle glaucoma , glaucoma , ophthalmology , gene , genotype , haplotype , biology , environmental health

Mutations in the MYOC gene have been shown to explain 5% of unrelated primary open angle glaucoma (POAG) in different populations. In particular, the T377M MYOC mutation has arisen at least three separate times in history, in Great Britain, India, and Greece. The purpose of this study is to investigate the distribution of the mutation among different population groups in the northwestern region of Greece.

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