Open AccessContribution of the R8 substituent to the in vitro antibacterial potency of besifloxacin and comparator ophthalmic fluoroquinolones
Author(s) -
Wolfgang Haas,
Christine M. Sanfilippo,
Timothy W. Morris,
Hesje
Publication year - 2013
Publication title -
clinical ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 56
eISSN - 1177-5483
pISSN - 1177-5467
DOI - 10.2147/opth.s44085
Subject(s) - potency , medicine , substituent , ophthalmology , optometry , in vitro , stereochemistry , chemistry , biochemistry
Previous work has shown that besifloxacin, an 8-chloro-fluoroquinolone, has more potent activity against gram-positive pathogens than moxifloxacin and gatifloxacin, which carry an 8-methoxy group. This study was conducted to determine the contribution of the R7 and R8 substituent to fluoroquinolone antibacterial activity.
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