Differential effects of interleukin-1&beta; and S100B on amyloid precursor protein in rat retinal neurons | Zendy

Peter J. Anderson | Zendy

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Differential effects of interleukin-1β and S100B on amyloid precursor protein in rat retinal neurons

Author(s) -

Peter J. Anderson

Publication year - 2009

Publication title -

clinical ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.025

H-Index - 56

eISSN - 1177-5483

pISSN - 1177-5467

DOI - 10.2147/opth.s2684

Subject(s) - retinal , nissl body , amyloid precursor protein , senile plaques , bace1 as , in vivo , blot , amyloid beta , pathogenesis , microbiology and biotechnology , medicine , chemistry , neuroscience , biology , alzheimer's disease , pathology , staining , biochemistry , ophthalmology , gene , disease

Interleukin-1beta (IL-1beta) and S100B calcium binding protein B (S100B) have been implicated in the pathogenesis of Alzheimer's disease. Both are present in and around senile plaques and have been shown to increase levels of amyloid precursor protein (APP) mRNA in vitro. However, it is not known how either of these substances affects APP in vivo.

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